Conference Day Two
Thursday April 25, 2024
8:15 am Registration & Coffee
9:15 am Chair’s Opening Remarks
Characterizing Exosomes for Standardization & Reliability of Future Use
9:30 am Understanding How to Characterize a Heterogenous Population of Exosomes for Successful Clinical Applications
Synopsis
- Discussing successful and unsuccessful control strategies and how this can inform future directions
- Evaluating the best strategy to characterize small and large exosomes and the type of vesicle
- Understanding exosome content will be critical to understand signalling of exosomes and understanding how they function
10:00 am Creating More Focus on Exosome Proteins & the Logistical Path to Differentiating Exosomes
Synopsis
- After isolating and quantifying pure batches of exosomes, understand differentiation for best effective usage
- Creating the standard for the proteins attached to the exosomes which help identify them
- Equally, identify contaminants and gaps which are causing error or negative data to inform future studies
10:30 am Morning Refreshments & Networking
Analyzing Exosome Cargo & Contents for Accurately Defined Functionality
11:00 am Critical Assessment of Biological Standards for Translational EV Flow Cytometry
Synopsis
- Discussing this recent paper’s results and findings
- Highlighting the key points of progression for both EV use and technological improvements
- Analyzing potential for future study and what this means for therapeutic use
11:30 am Case Study: The Challenges Of The Innovative Exosomes-Based Therapies
Synopsis
- Â Highlighting the key advantages but also challenges of continuing development of exosome-based therapies
- Understanding the regulatory pathway and why exosomes are not considered as ATMP
- Learning how ExoBiologics became the first company authorized by the EMA for clinical trials of MSC derived exosomes
12:00 pm Lunch & Networking
Advancing Analytical Technologies for Regulatory Considerations
1:00 pm Reviewing the Current Technology Limitations & Potential for New Technologies
Synopsis
- Highlighting limits of detection and quantification for specific cargo
- Understanding why inconsistent sensitivity of technologies is still a significant hinderance in using exosomes
- Discussing where gaps need to be filled in the current available technology to aid future study success
1:30 pm Session Reserved for NanoFCM
Synopsis
Details to be announced
1:30 pm Session Reserved for NanoFCM
Synopsis
- Details to be announced.
1:45 pm Case Study: Recombinant Nanovesicles for Therapeutic & Vaccine Delivery
Synopsis
- Understanding advantages of using microbial nanovesicles for vaccines
- Discovering better techniques analytical assays and characterization
- Defining transferable methods for future studies
2:15 pm Afternoon Refreshments & Networking
Developing Standardization of Exosomes for Diagnostics, Therapeutics & Drug Delivery
3:00 pm Case Study: Inhaled Extracellular Vesicle Encapsulated RNA for Respiratory Disease Therapeutics
Synopsis
- Discussing efficient delivery of the EVs directly to the site of interest
- Developing accurate characterization and standardization of therapeutic EVs
- Evaluating roadblocks with current analytical techniques for EV cargo quantification
3:30 pm Roundtable Discussion: Evaluating Exosomes Based Products for Diagnosis, Drug Delivery & Therapeutics
Synopsis
- Understanding the advantages and limitations of engineering exosomes as therapeutics and as drug delivery vehicles
- Linking engineering to the successful loading of cargo artificially
- Enhancing future pipelines using comparison of resultsÂ